Whoever said that we went to the Moon a half-century early may have had a point. Apollo was a tour de force, but only now is the tech infrastructure emerging to repeat it sustainably, affordably, and profitably.Osteoparosis develops in orbit. Afaik not even animal breeding has been tested in non-terrestrial gravity.
Though IMHO it may take additional decades of biology before humans can reside off-planet (and return).
Though there is no substitute for boots on the ground, in my reflective moments our planetary fly-by's seem more praiseworthy than Apollo.